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Gardasil 9 prescribing information. In: Abeloff's Clinical Oncology. Show references Deng GE, et al. This content does not have an Arabic version. Most people with anal cancer are treated with a combination of chemotherapy and radiation. Mayo Clinic does not endorse companies or products. Anal cancer is closely related to a sexually transmitted infection called human papillomavirus HPV. Anal cancer forms when a genetic mutation turns normal, healthy cells into abnormal cells. Talk to your doctor about any signs and symptoms that bother you, especially if you have any factors that increase your risk of anal cancer.

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